WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: The Gout, xanthine made from Hypoxanthine, pain in the big toe, lactic acid increased levels causes lactic acidosis, probenicid increases renal exretion of uric acid, renal insufficiency characterized by a decrease GFR, Chris Turtle (AKA Gout Boy) presents with hypertension, elevated Creatinine level suggests renal insufficiency, diuretic blocks Na–K– 2Cl cotransporter in nephron, lactic acid out competes with uric acid for secretion by the renal tubules, results in uricemia, Guanine converted via HGPRT, ETOH high levels of ETOH shunt pyruvate to lactic acid, Purine rich foods metabolism leads to increased levels of uric acid, elevated serum uric acid caused by over production of or underexcretion of uric acid, Purines salvage helps to decrease concentration of uric acid, "partying like the old days" including ETOH, xanthine made from Guanine, Na–K– 2Cl cotransporter in nephron causes fluid loss, febuxostat allows salvage of Purines, inflammation cascade leads to swelling, blood volume contraction causes supersaturation and therefore increased precipitation of uric acid